Description

8-Nitroguanine is a high-purity, nitrated derivative of the nucleobase guanine, identified by CAS NO 168701-80-2. This compound serves as a critical building block and reference standard in advanced chemical and biochemical research. It is primarily utilized by research institutions and pharmaceutical development teams working on nucleic acid chemistry, mutagenesis studies, and the synthesis of novel nucleoside analogs.

Application

• Biochemical Research: Used as a reference standard and probe in studies of DNA damage, oxidative stress, and nitrosative guanine modifications.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor in the development of novel nucleoside-based therapeutics and diagnostic agents.
• Mutagenesis Studies: Employed in laboratory research to understand the mechanisms of nitro-substituted base analogs and their biological impacts.
• Organic Synthesis: Acts as a specialized building block for synthesizing complex heterocyclic compounds and labeled nucleosides.
• Analytical Standards: Provides a high-purity standard for analytical method development and validation in HPLC, LC-MS, and other chromatographic techniques.

Basic Information

Product Name	8-Nitroguanine
CAS No.	168701-80-2
Molecular Formula	C5H4N6O3
Molecular Weight	196.12 g/mol
Synonyms	8-Nitro-guanine; Guanin-8-nitrat; 8-Nitro-1H-purin-6(9H)-one; 8-Nitro-9H-purin-6-ol; 6-Hydroxy-8-nitropurine; 8-Nitro-6-hydroxypurine; 8-Nitro-1,7-dihydro-6H-purin-6-one
EINECS	Contact for details

Quality Control

Our 8-Nitroguanine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, minimize exposure during handling.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.