Description

Vofopitant Dihydrochloride CAS NO 168266-51-1 is a high-purity, small molecule pharmaceutical intermediate and reference standard of significant importance in modern drug development. This compound is a potent and selective neurokinin-1 (NK1) receptor antagonist, making it a critical tool for research into emesis, pain, and central nervous system disorders. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for use in preclinical studies, analytical method development, and quality control processes.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity assessment, and quantification of Vofopitant in analytical methods like HPLC and LC-MS.
• Preclinical Research & Development: Serves as a key intermediate and biological probe in studies targeting the NK1 receptor pathway for antiemetic and analgesic applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed as a building block in the scaled-up production of finished drug substances for clinical trials.
• Biochemical Assay Development: Utilized in vitro to screen for NK1 receptor activity and to validate new assay platforms.
• Academic Research: Supports university and institutional studies investigating neurokinin signaling mechanisms and related therapeutic areas.
• Quality Control & Regulatory Compliance: Essential for generating Certificates of Analysis (CoA) and meeting regulatory submission requirements for drug master files.

Basic Information

Product Name	Vofopitant Dihydrochloride
CAS No.	168266-51-1
Molecular Formula	C32H34N4O3 · 2HCl
Molecular Weight	595.56 g/mol
Synonyms	Vofopitant HCl; GR 205171; (2S,3S)-2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride; GR205171; Vofopitant 2HCl; (3-endo)-2-(Diphenylmethyl)-N-[[2-(methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride; NK1 Receptor Antagonist GR205171; Vofopitant Dihydrochloride Salt
EINECS	Contact for details

Quality Control

Our Vofopitant Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (CoA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.