Description

6,7-Dimethyltetrahydropterin Hydrochloride is a high-purity, chemically synthesized derivative of tetrahydropterin, a critical cofactor in enzymatic reactions. This compound is essential for research and development in biochemistry and pharmaceutical sciences, where it serves as a key reagent in studies of nitric oxide synthases, aromatic amino acid hydroxylases, and other pterin-dependent enzymes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on neurochemistry, metabolic pathway analysis, and the development of diagnostic assays.

Application

• Biochemical Research: Acts as a crucial cofactor or substrate in enzymatic studies, particularly for nitric oxide synthase (NOS) and phenylalanine hydroxylase (PAH) assays.
• Pharmaceutical R&D: Used in the investigation of metabolic pathways and the development of potential therapeutic agents targeting neurotransmitter synthesis and vascular function.
• Diagnostic Reagent Manufacturing: Serves as a key component in the formulation of diagnostic kits for inborn errors of metabolism, such as phenylketonuria (PKU).
• Enzyme Kinetics & Inhibition Studies: Employed to study enzyme mechanisms, kinetics, and to screen for enzyme inhibitors in high-throughput settings.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in laboratory testing.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the role of tetrahydrobiopterin pathways in cellular physiology and disease models.

Basic Information

Product Name	6,7-Dimethyltetrahydropterin Hydrochloride
CAS No.	167423-51-0
Molecular Formula	C9H17N5O2 • HCl
Molecular Weight	279.73 g/mol (Free base: 243.27 g/mol)
Synonyms	6,7-Dimethyl-5,6,7,8-tetrahydropterin hydrochloride; 6,7-Dimethyl-5,6,7,8-tetrahydrobiopterin hydrochloride; 6,7-Dimethyl-BH4 HCl; 6,7-DMTHP HCl; 6,7-Dimethyltetrahydrobiopterin hydrochloride; 6,7-Dimethyl-H4-biopterin hydrochloride; (6R,S)-6,7-Dimethyl-5,6,7,8-tetrahydropterin hydrochloride
EINECS	Contact for details

Quality Control

Our 6,7-Dimethyltetrahydropterin Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.