Description

Dc-Chol is a specialized cationic lipid compound widely recognized for its critical role in nucleic acid delivery and transfection research. This high-purity chemical is essential for formulating lipid nanoparticles (LNPs), which are foundational to modern gene therapy and mRNA vaccine development. Key industries that rely on this material include pharmaceutical R&D, biotechnology, and advanced therapeutic medicinal product (ATMP) manufacturing, where it is used to create efficient and safe delivery systems for genetic material.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural and functional component for encapsulating mRNA, siRNA, and other nucleic acids.
• Gene Delivery & Transfection Reagents: Used in research to develop non-viral vectors for delivering genetic material into cells in vitro and in vivo.
• mRNA Vaccine & Therapeutic Development: Critical for creating the delivery vehicle in cutting-edge vaccine and gene therapy platforms.
• Bioconjugation & Linker Chemistry: Serves as a building block for synthesizing more complex, targeted lipid conjugates.
• Drug Delivery System (DDS) Research: Employed in the design of advanced nanocarriers for targeted and controlled release of therapeutics.
• Academic & Industrial R&D: A standard reagent in laboratories focused on molecular biology, nanomedicine, and pharmaceutical sciences.

Basic Information

Item	Detail
Product Name	Dc-Chol
CAS No.	166023-21-8
Molecular Formula	C44H80N2O5
Molecular Weight	717.1 g/mol
Synonyms	3β-[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol; DC-Cholesterol; DC-Chol Hydrochloride (salt form); Dimethylaminoethane-carbamoyl Cholesterol; Cholesteryl 3β-oxycarbonyl-3'-dimethylaminopropylamine; N,N-Dimethylaminoethylcarbamoylcholesterol; Cationic Lipid DC-Chol; Lipofectamine component analog
EINECS	Contact for details

Quality Control

Our Dc-Chol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant GMP and ISO guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.