Description

Trifluoperazine n-β-D-Glucuronide is a high-purity reference standard and metabolite of the antipsychotic drug trifluoperazine. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of trifluoperazine and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance, and bioavailability of trifluoperazine.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring (TDM).
• Clinical Toxicology & Forensic Analysis: Employed as an analytical standard in assays to detect and quantify trifluoperazine exposure in clinical or forensic samples.
• Impurity Profiling: Used in the identification and control of glucuronidated metabolite impurities in active pharmaceutical ingredient (API) batches.
• Enzymology Research: Acts as a substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in Phase II drug metabolism.

Basic Information

Product Name	Trifluoperazine n-β-D-Glucuronide
CAS No.	165602-90-4
Molecular Formula	C29H38F3N3O7S
Molecular Weight	629.69 g/mol
Synonyms	Trifluoperazine N-Glucuronide; Trifluoperazine Glucuronide; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine Glucuronide; Trifluoperazine β-D-Glucopyranosiduronic Acid; Trifluoperazine Metabolite Glucuronide; NSC 401005; Trifluoperazine N-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Trifluoperazine n-β-D-Glucuronide is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.