Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphatidylethanolamino (+)-Biotin is a high-purity, synthetic phospholipid derivative covalently linked to biotin, designed for advanced bioconjugation and surface immobilization applications. This compound is critical for creating stable, high-affinity linkages in biomolecular research and diagnostic assay development. It is an essential reagent for pharmaceutical R&D, biotechnology, and life science laboratories focusing on liposome technology, targeted drug delivery systems, and biosensor fabrication.

Application

• Liposome & Nanoparticle Functionalization: For creating biotinylated lipid bilayers to enable streptavidin-mediated targeting and conjugation in drug delivery vehicles.
• Biosensor & Diagnostic Assay Development: As a key component for immobilizing biomolecules (e.g., antibodies, receptors) onto sensor surfaces via biotin-streptavidin bridges.
• Membrane Protein Studies: Used in the reconstitution and labeling of membrane proteins for structural and functional analysis.
• Cell Surface Engineering: For incorporating biotin tags into cellular membranes to study cell-cell interactions, adhesion, and signaling.
• Affinity Chromatography: As a ligand for preparing streptavidin-column stationary phases used in the purification of biomolecules.
• Biophysical Research: In model membrane systems (e.g., supported lipid bilayers) to investigate lipid-protein interactions and membrane dynamics.

Basic Information

Item	Detail
Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphatidylethanolamino (+)-Biotin
CAS No.	165191-88-8
Molecular Formula	C89H159N4O10PS
Molecular Weight	1524.2 g/mol
Synonyms	Biotinylated DOPE; Biotin-DOPE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl); DOPE-Biotin; N-(Biotinoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Biotinyl-DOPE; Biotin PE; Biotin Phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Every batch of 1,2-Dioleoyl-Sn-Glycero-3-Phosphatidylethanolamino (+)-Biotin is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent purity standards suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA), including HPLC purity, identity confirmation, and impurity profiles, is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Once opened, use promptly and reseal under inert gas.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.