Description

Methoxypolyethylene Glycol 5,000 2-(Vinylsulfonyl)Ethyl Ether is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive vinyl sulfone group and a terminal methoxy group. This compound is engineered for site-specific conjugation and bioconjugation applications, offering a controlled, stable linkage under mild conditions. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, protein engineering, and advanced material science, where precise modification of biomolecules is required.

Application

• Bioconjugation and PEGylation: Site-specific modification of proteins, peptides, and antibodies to enhance stability, solubility, and pharmacokinetic profiles.
• Hydrogel Formation: Cross-linking agent for creating biocompatible hydrogels used in drug delivery systems and tissue engineering scaffolds.
• Surface Functionalization: Immobilization of biomolecules onto sensor chips, nanoparticles, or diagnostic assay platforms via the reactive vinyl sulfone group.
• Linker Chemistry: Used as a heterobifunctional spacer arm to connect different molecules, such as drugs to targeting ligands or fluorophores to proteins.
• Polymer-Protein Conjugates: Synthesis of advanced therapeutic conjugates where controlled polymer architecture is crucial for function.
• Diagnostic Reagent Synthesis: Production of labeled probes and reagents for immunoassays and other diagnostic applications.

Basic Information

Product Name	Methoxypolyethylene Glycol 5,000 2-(Vinylsulfonyl)Ethyl Ether
CAS No.	165125-59-7
Molecular Formula	C2n+5H4n+10On+3S (n ~ 113)
Molecular Weight	~5,000 g/mol (Average Mn)
Synonyms	mPEG-VS (MW 5000); mPEG-Vinylsulfone; Methoxy PEG Vinylsulfone; Poly(ethylene glycol) methyl ether vinylsulfone; PEG-VS; 2-(Vinylsulfonyl)ethoxy poly(ethylene glycol) methyl ether; α-Methyl-ω-(2-(vinylsulfonyl)ethoxy)poly(oxy-1,2-ethanediyl)
EINECS	Contact for details

Quality Control

Our Methoxypolyethylene Glycol 5,000 2-(Vinylsulfonyl)Ethyl Ether is manufactured under strict quality management systems. Each batch is characterized to ensure consistent molecular weight, low polydispersity, and high functional group purity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, degree of substitution, and impurity profiles. We support cGMP manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	5,000 ± 10% (by GPC/MALDI-TOF)
Polydispersity Index (PDI)	≤ 1.05
Assay (Functional Group)	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.