Description

n-Desmethyl Tamoxifen-D5 is a deuterated internal standard of the active metabolite of the selective estrogen receptor modulator (SERM) tamoxifen. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical assays. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, therapeutic drug monitoring, and metabolism research for tamoxifen and related therapeutics.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods for the precise quantification of endoxifen (4-hydroxy-N-desmethyltamoxifen) and related metabolites in biological matrices.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug concentration-time profiles to understand absorption, distribution, metabolism, and excretion (ADME) of tamoxifen in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Supports assay development and validation for monitoring tamoxifen and endoxifen levels in patient plasma/serum to optimize dosing regimens and improve breast cancer treatment outcomes.
• Metabolite Identification & Profiling: Aids in the structural confirmation and quantitative analysis of tamoxifen metabolites during drug metabolism studies.
• Method Development & Validation: Used as a reference standard to develop, optimize, and validate robust analytical methods in compliance with GLP (Good Laboratory Practice) and FDA/EMA guidelines.
• Clinical Research: Facilitates reliable data generation in clinical trials investigating tamoxifen efficacy, toxicity, and personalized medicine approaches based on CYP2D6 metabolizer status.

Basic Information

Product Name	n-Desmethyl Tamoxifen-D5
CAS No.	164365-16-6
Molecular Formula	C25H24D5NO
Molecular Weight	373.58 g/mol
Synonyms	4-Hydroxytamoxifen-d5 Metabolite; Endoxifen-d5; (Z)-4-Hydroxy-N-desmethyltamoxifen-d5; N-Desmethyl-4-hydroxytamoxifen-d5; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene-d5; Z-Endoxifen-d5; Tamoxifen Metabolite-d5; ER-115781-d5
EINECS	Contact for details

Quality Control

Our n-Desmethyl Tamoxifen-D5 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters. We support research and development that adheres to GLP and other relevant quality frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the product to reach room temperature in a desiccator before opening to prevent condensation. The material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.