Description

Thiocolchicoside Tetraacetate is a chemically modified derivative of the natural alkaloid thiocolchicoside, characterized by the acetylation of its hydroxyl groups. This modification enhances its lipophilicity and stability, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of neurology and musculoskeletal research, where its parent compound is known for its muscle relaxant properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new muscle relaxant and anti-inflammatory drug candidates.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) of colchicine and thiocolchicoside derivatives.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Medicinal Chemistry: A crucial building block for the synthesis of novel chemical entities targeting GABAergic pathways and other neurological receptors.
• Process Development: Utilized in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in pilot plants.

Basic Information

Product Name	Thiocolchicoside Tetraacetate
CAS No.	163956-01-2
Molecular Formula	C31H37NO11S
Molecular Weight	631.70 g/mol
Synonyms	Thiocolchicoside 2',3,4',6'-Tetraacetate; N-[(7S)-3-(β-D-Glucopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 2',3,4',6'-Tetraacetate; Thiocolchicine Tetraacetate Glucoside; Colchicoside Tetraacetate Derivative
EINECS	Contact for details

Quality Control

Our Thiocolchicoside Tetraacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.