Description

Boc-3,5-Diiodo-Tyr-Osu CAS NO 163679-35-4 is a protected, activated ester derivative of tyrosine, specifically designed for peptide synthesis. This compound is a critical building block for the controlled, site-specific introduction of iodinated tyrosine residues into peptide chains, enabling advanced research in radiopharmaceuticals and molecular imaging. It is primarily utilized by pharmaceutical R&D teams, peptide synthesis specialists, and academic researchers focused on developing novel diagnostic and therapeutic agents.

Application

• Peptide Synthesis: Key intermediate for the solid-phase and solution-phase synthesis of complex peptides containing modified tyrosine.
• Radiopharmaceutical Precursor: Serves as a precursor for radioiodination, enabling the creation of labeled peptides for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging.
• Bioconjugation & Probe Development: Used to incorporate iodine atoms into bioactive peptides for creating molecular probes, affinity labels, and enzyme inhibitors.
• Structure-Activity Relationship (SAR) Studies: Facilitates the study of peptide hormone analogs by allowing precise halogenation to investigate receptor binding and stability.
• API Intermediate: An important synthetic intermediate in the development of active pharmaceutical ingredients (APIs) targeting endocrine and neurological disorders.

Basic Information

Product Name	Boc-3,5-Diiodo-Tyr-Osu
CAS No.	163679-35-4
Molecular Formula	C18H22I2N2O7
Molecular Weight	640.09 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-3,5-diiodo-L-tyrosine N-hydroxysuccinimide ester; Boc-Tyr(3,5-I2)-OSu; Boc-L-3,5-Diiodotyrosine N-succinimidyl ester; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(3,5-diiodo-4-hydroxyphenyl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; Boc-3,5-Diiodo-L-tyrosine-OSu; tert-Butyloxycarbonyl-3,5-diiodo-L-tyrosine N-hydroxysuccinimide ester; 3,5-Diiodo-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosine N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our Boc-3,5-Diiodo-Tyr-Osu is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.