Description

Hydrodolasetron is a selective serotonin 5-HT3 receptor antagonist, a key pharmaceutical intermediate in the synthesis of advanced antiemetic medications. Its primary value lies in enabling the production of therapeutics that effectively prevent nausea and vomiting, particularly in patients undergoing chemotherapy or radiation treatment. This compound is essential for manufacturers in the global pharmaceutical and fine chemical sectors focused on developing and producing critical care drugs. Precise synthesis and high purity are paramount for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API).

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of Dolasetron mesylate and related 5-HT3 antagonist APIs.
• Antiemetic Drug Production: Integral to manufacturing medications designed to prevent and treat chemotherapy-induced nausea and vomiting (CINV).
• Postoperative Nausea Management: Used in the development of drugs aimed at controlling nausea and vomiting following surgical procedures.
• Research & Development: Serves as a reference standard and starting material in pharmacological research for novel serotonin receptor modulators.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for complex organic molecules within contract manufacturing organizations (CMOs).

Basic Information

Product Name	Hydrodolasetron
CAS No.	163253-02-9
Molecular Formula	C19H20N2O3
Molecular Weight	324.38 g/mol
Synonyms	Hydrodolasetron; (1S,3R)-1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one; Reduced Dolasetron; MDL 73,147EF; UNII-3W0P2SX49Q; Dolasetron Impurity; Dolasetron Related Compound A
EINECS	Contact for details

Quality Control

Our Hydrodolasetron is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical intermediate use. We provide comprehensive Certificates of Analysis (COA) that detail identity, purity, and impurity profiles, supporting compliance with cGMP and ICH Q7 guidelines. Specifications are aligned with industry pharmacopeial expectations for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.