Description

25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether is a key chemical intermediate in the synthesis of advanced vitamin D analogs and other biologically active compounds. This modified form of calcifediol offers a reactive amino group, enabling its use in targeted drug development and biochemical research. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on endocrinology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel vitamin D receptor (VDR) agonists and antagonists for therapeutic applications.
• Bioconjugation: The aminopropyl ether moiety serves as a linker for attaching vitamin D derivatives to carrier molecules, nanoparticles, or solid supports.
• Pro-drug Development: Used to create water-soluble or targeted pro-drugs of active vitamin D metabolites to improve bioavailability and reduce side effects.
• Biochemical Research: A valuable tool compound for studying vitamin D metabolism, receptor binding, and signaling pathways in vitro.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related vitamin D analogs.
• Chemical Biology Probes: Enables the creation of fluorescently tagged or affinity-labeled probes for cellular imaging and protein interaction studies.

Basic Information

Product Name	25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether
CAS No.	163018-26-6
Molecular Formula	C30H53NO2
Molecular Weight	459.75 g/mol
Synonyms	Calcifediol 3,3'-Aminopropyl Ether; 25-Hydroxycholecalciferol 3,3'-Aminopropyl Ether; 3-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-Hydroxy-2-methylene-1-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propylamine; 25(OH)D3-AP; 25-Hydroxy Vitamin D3 APE; 25-Hydroxyvitamin D3 Aminopropyl Ether
EINECS	Contact for details

Quality Control

Our 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.