Description

(S)-Flurbiprofen-Acyl-β-D-Glucuronide Min. 98% is a high-purity, stereochemically defined metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) Flurbiprofen. This compound is critical for advanced pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is an essential material for scientists and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require definitive standards for accurate analysis and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Primary use as an analytical standard for the quantification and identification of Flurbiprofen metabolites in biological matrices (plasma, urine) during preclinical and clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Investigating the Phase II glucuronidation metabolic pathway of (S)-Flurbiprofen to understand its clearance, bioavailability, and potential drug-drug interactions.
• Bioanalytical Method Development & Validation: Serving as a critical calibrator and quality control sample in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS/MS) assays to ensure method accuracy, precision, and regulatory compliance (e.g., FDA, EMA guidelines).
• Impurity Profiling and Characterization: Used to identify and quantify specific glucuronidated impurities or degradants in active pharmaceutical ingredient (API) and finished drug product stability studies.
• Toxicology Studies: Aiding in the assessment of metabolite-specific toxicity and safety profiles as part of comprehensive non-clinical safety evaluations.

Basic Information

Product Name	(S)-Flurbiprofen-Acyl-β-D-Glucuronide Min. 98%
CAS No.	162992-66-7
Molecular Formula	C25H25FO8
Molecular Weight	472.46 g/mol
Synonyms	(S)-Flurbiprofen 1-O-β-Acyl Glucuronide; (S)-Flurbiprofen Acyl Glucuronide; (2S)-2-(3-Fluoro-4-phenylphenyl)propanoic acid 1-(β-D-glucopyranuronosyl) ester; Flurbiprofen S-Glucuronide; (S)-Flurbiprofen β-D-Glucuronide; Flurbiprofen Acyl-β-D-Glucuronide (S-isomer); Flurbiprofen metabolite glucuronide
EINECS	Contact for details

Quality Control

Every batch of (S)-Flurbiprofen-Acyl-β-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	Min. 98.0%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.