Description

2,3,9,10-Tetrahydroxyberberine is a highly functionalized derivative of the natural alkaloid berberine, characterized by the addition of four hydroxyl groups to its core structure. This chemical modification significantly enhances its potential for research and development in advanced pharmaceutical and biochemical applications. It is primarily sought by researchers and manufacturers in the pharmaceutical, nutraceutical, and fine chemical synthesis sectors for its unique biological activity and as a key intermediate.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and a key intermediate in the synthesis of novel therapeutic agents, particularly for metabolic and inflammatory pathway studies.
• Biochemical Research: Used as a tool compound in enzymatic and cellular assays to investigate its antioxidant and potential signaling properties.
• Natural Product Chemistry: Acts as a benchmark compound for the analysis and quality control of berberine-containing herbal extracts and supplements.
• Fine Chemical Synthesis: Employed as a sophisticated building block for the preparation of more complex, polyhydroxylated alkaloid derivatives with tailored properties.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies on plant alkaloid chemistry and bioactivity.

Basic Information

Product Name	2,3,9,10-Tetrahydroxyberberine
CAS No.	162854-37-7
Molecular Formula	C₂₀H₁₉NO₈
Molecular Weight	401.37 g/mol
Synonyms	2,3,9,10-Tetrahydroxyberberine; Berberine, 2,3,9,10-tetrahydroxy-; 2,3,9,10-Tetrahydroxy-berberine; THB; Tetrahydroxyberberine; 2,3,9,10-Tetrahydroxyberberin; 2,3,9,10-Tetrahydroxyberberine chloride (if applicable); Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our 2,3,9,10-Tetrahydroxyberberine is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.