Description

2,6-Bis[(4S)-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-2-Oxazolyl]Pyridine is a high-purity, chiral oxazoline-based ligand of significant importance in asymmetric synthesis. Its value lies in its ability to act as a highly effective and selective catalyst or ligand in transition metal-catalyzed reactions, enabling the production of enantiomerically pure compounds. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced intermediates and active ingredients.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand for transition metals like palladium, rhodium, and iridium in C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediates: Enabling the synthesis of enantiomerically pure building blocks for active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Facilitating the production of chiral herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Fine Chemical Manufacturing: Used in the preparation of specialty chemicals, flavors, and fragrances requiring high enantiomeric excess.
• Academic & Industrial R&D: A critical tool for methodological development in organic synthesis and catalysis research.
• Material Science: Potential application in the synthesis of chiral polymers or as a component in advanced molecular recognition systems.

Basic Information

Product Name	2,6-Bis[(4S)-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-2-Oxazolyl]Pyridine
CAS No.	162213-03-8
Molecular Formula	C43H41N3O2
Molecular Weight	631.81 g/mol
Synonyms	(S,S)-2,6-Bis(4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine; PyBOX-(i-Pr)Ph; (S,S)-i-Pr-PyBOX; (S,S)-2,6-Bis[4,5-dihydro-4-(1-methylethyl)-5,5-diphenyl-2-oxazolyl]pyridine; (S,S)-2,6-Bis(4-isopropyl-2-oxazolin-2-yl)pyridine derivative; Chiral Pyridine-bis(oxazoline) ligand; (S,S)-iPr-PyBOX-Ph; (4S,4'S)-2,6-Bis(4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our production of 2,6-Bis[(4S)-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-2-Oxazolyl]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized and tested using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.