Description

20-Fluoroarachidonic Acid is a fluorinated analog of the essential ω-6 fatty acid arachidonic acid, where a fluorine atom is strategically substituted at the C-20 position. This modification creates a valuable biochemical tool and synthetic intermediate, as the fluorine atom can act as a bioisostere or a metabolic blocker, altering the compound's interaction with enzymes in the eicosanoid biosynthesis pathway. This product is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and as a reference standard for lipidomics and metabolic studies.

Application

• Biochemical Research: Used as a mechanistic probe to study the metabolism of arachidonic acid, particularly the lipoxygenase (LOX) and cyclooxygenase (COX) enzyme pathways.
• Pharmaceutical Development: Serves as a key synthetic intermediate or a molecular template for developing novel anti-inflammatory agents and enzyme inhibitors.
• Metabolic Studies: Employed in lipidomics to investigate fluorinated lipid incorporation into cell membranes and their subsequent biological effects.
• Reference Standard: Essential for analytical method development, validation, and quality control in laboratories analyzing complex lipid mixtures.
• Enzyme Inhibition Assays: Acts as a potential inhibitor or alternative substrate in high-throughput screening for drug discovery targeting eicosanoid-related diseases.

Basic Information

Product Name	20-Fluoroarachidonic Acid
CAS No.	161882-27-5
Molecular Formula	C₂₀H₃₁FO₂
Molecular Weight	322.46 g/mol
Synonyms	(5Z,8Z,11Z,14Z)-20-Fluoroicosa-5,8,11,14-tetraenoic Acid; 20-Fluoro-5Z,8Z,11Z,14Z-eicosatetraenoic Acid; 20-F-AA; 20-Fluoro-AA; Fluoroarachidonic Acid; 20-Fluoroarachidonate; 20-Fluoroeicosa-5,8,11,14-tetraenoic Acid
EINECS	Contact for details

Quality Control

Our 20-Fluoroarachidonic Acid is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 97% (by titration or quantitative NMR)
Solubility	Soluble in ethanol, DMSO, DMF; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.