Description

(S)-(+)-Glycidyl Phthalimide is a high-purity, single-enantiomer chiral building block and intermediate of significant importance in asymmetric synthesis. Its value lies in its reactive epoxide and phthalimide functional groups, which enable the stereoselective introduction of nitrogen-containing moieties into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise chirality control for developing active pharmaceutical ingredients (APIs), chiral ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure β-amino alcohols and other nitrogen-containing bioactive molecules.
• Asymmetric Catalyst & Ligand Synthesis: Serves as a precursor for developing novel chiral catalysts and auxiliaries used in stereoselective transformations.
• Agrochemical Active Ingredient Development: Used in the research and production of chiral pesticides and herbicides where specific stereochemistry is critical for activity.
• Polymer Modification: Employed as a reactive monomer or cross-linking agent to introduce chiral centers or imide functionality into specialty polymers and resins.
• Academic & Process Chemistry Research: A valuable tool for methodological development in organic synthesis and scale-up process optimization.
• Fine Chemical Synthesis: Intermediate for producing other high-value, optically pure fine chemicals and custom synthesis projects.

Basic Information

Product Name	(S)-(+)-Glycidyl Phthalimide
CAS No.	161596-47-0
Molecular Formula	C11H9NO3
Molecular Weight	203.19 g/mol
Synonyms	(S)-(+)-2-Phthalimidomethyloxirane; (S)-Glycidyl Phthalimide; (S)-(-)-2-Phthalimidomethyloxirane (enantiomer); (2S)-2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]oxirane; (S)-N-(Oxiran-2-ylmethyl)phthalimide; (+)-(S)-Glycidyl Phthalimide; N-[(2S)-Oxiran-2-ylmethyl]phthalimide; Chiral Glycidyl Phthalimide
EINECS	Contact for details

Quality Control

Our (S)-(+)-Glycidyl Phthalimide is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to meet the stringent requirements of advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	97 - 102 °C
Loss on Drying	≤ 0.5%
Specific Rotation ([α]D20)	+15.0° to +18.0° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.