Description

Umbelliferyl Arachidonate is a specialized fluorogenic substrate designed for the sensitive detection and quantification of phospholipase A2 (PLA2) enzyme activity. This compound is critical for researchers and quality control laboratories requiring precise enzymatic assays in biochemical and pharmaceutical development. It is primarily utilized in life science research, diagnostic kit manufacturing, and drug discovery programs targeting inflammatory pathways.

Application

• Enzymatic Assay Substrate: A fluorogenic substrate for the continuous, real-time monitoring of secreted phospholipase A2 (sPLA2) activity in vitro.
• High-Throughput Screening (HTS): Used in drug discovery campaigns to identify and characterize novel PLA2 inhibitors for anti-inflammatory therapeutics.
• Diagnostic Development: Employed in the research and development of clinical diagnostic assays for conditions involving altered PLA2 levels.
• Biochemical Research: A key tool for studying the kinetics, mechanism, and regulation of phospholipase A2 enzymes in cell signaling and lipid metabolism.
• Quality Control: Used in the pharmaceutical industry to test the potency and consistency of enzyme-based biopharmaceuticals.

Basic Information

Product Name	Umbelliferyl Arachidonate
CAS No.	161180-11-6
Molecular Formula	C₃₀H₄₄O₅
Molecular Weight	484.67 g/mol
Synonyms	7-Hydroxycoumarin-4-yl arachidonate; 4-Methylumbelliferyl Arachidonate; 4-MU Arachidonate; Arachidonic Acid 7-Hydroxy-4-methylcoumarin Ester; 7-Hydroxy-4-methylcoumarin Arachidonate; Fluorogenic PLA2 Substrate; sPLA2 Substrate IV
EINECS	Contact for details

Quality Control

Our Umbelliferyl Arachidonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.