Description

Xanthosine-[8-3H] 5'-Triphosphate Tetraammonium Salt is a high-purity, tritium-labeled nucleotide derivative essential for advanced biochemical research. This radiolabeled compound serves as a critical tracer for studying nucleotide metabolism, enzyme kinetics, and nucleic acid synthesis pathways. It is primarily utilized by research scientists and pharmaceutical developers in life sciences, molecular biology, and drug discovery for sensitive detection and quantification assays.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a radiolabeled substrate to investigate the activity and inhibition of kinases, polymerases, and other nucleotide-processing enzymes.
• Nucleic Acid Research: Employed in the study of RNA synthesis, modification, and degradation pathways, providing a traceable probe for metabolic labeling.
• Biochemical Assay Development: Acts as a key component in developing high-throughput screening (HTS) assays for drug discovery targeting nucleotide-binding proteins.
• Metabolic Pathway Tracing: Enables the detailed mapping of purine and nucleotide salvage pathways in cellular systems.
• Autoradiography & Imaging: Provides a detectable signal for use in blotting techniques, autoradiography, and other imaging applications to visualize nucleotide incorporation.
• Quality Control for Diagnostic Kits: Used as a reference standard in the production and validation of diagnostic kits that measure nucleotide-related enzyme activities.

Basic Information

Product Name	Xanthosine-[8-3H] 5'-Triphosphate Tetraammonium Salt
CAS No.	160901-65-5
Molecular Formula	C10H21N7O14P3 • x(NH4)
Molecular Weight	Contact for details
Synonyms	3H-Xanthosine-5'-triphosphate tetraammonium salt; [8-3H]XTP tetraammonium salt; Tritiated XTP; XTP-[8-3H]; Xanthosine 5'-triphosphate, [8-3H]-; 5'-XTP-[3H]; Radiolabeled xanthosine triphosphate; 8-Tritio-xanthosine-5'-triphosphate tetraammonium salt
EINECS	Contact for details

Quality Control

Our Xanthosine-[8-3H] 5'-Triphosphate Tetraammonium Salt is manufactured under controlled conditions to ensure exceptional purity and specific activity. Each batch undergoes rigorous analytical testing, including HPLC for radiochemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing specific activity, purity, and solvent composition is provided with every shipment to guarantee consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as supplied. For long-term storage, keep at -70°C to minimize radiolytic decomposition. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Clear solution
Identification (HPLC)	Conforms
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-40 Ci/mmol
Chemical Purity (HPLC)	≥ 90%
Solvent	Aqueous buffer, ethanol, or as specified
Concentration	1 mCi/mL (typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.