Description

Fmoc-L-Valinol CAS NO 160885-98-3 is a high-purity, protected amino alcohol derivative, specifically the 9-fluorenylmethoxycarbonyl (Fmoc) derivative of L-valinol. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering excellent stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in solid-phase peptide synthesis (SPPS) and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of the valinol moiety into peptide chains, enabling the creation of peptides with modified backbones or termini.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, prodrugs, and bioactive molecules where the valinol structure is pharmacologically relevant.
• Peptidomimetic Design: Essential for constructing non-natural peptide analogs that mimic the structure and function of native peptides but with enhanced metabolic stability or bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions, enzyme mechanisms, and cellular processes.
• Chiral Auxiliary and Ligand Synthesis: The chiral valinol scaffold can be utilized to develop asymmetric catalysts or chiral ligands for enantioselective synthesis.
• Academic and Industrial Research: A fundamental reagent for organic and medicinal chemistry laboratories exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	Fmoc-L-Valinol
CAS No.	160885-98-3
Molecular Formula	C₂₀H₂₃NO₃
Molecular Weight	325.40 g/mol
Synonyms	(2S)-3-Methyl-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butan-1-ol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valinol; Fmoc-Valinol; N-Fmoc-L-valinol; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutan-1-ol; Fmoc-L-2-Amino-3-methyl-1-butanol; L-Valinol, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-L-Valinol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing specific batch results are available upon request, providing full traceability and quality assurance for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.