Description

Methohexital-D5 is a deuterated analog of the short-acting barbiturate anesthetic, Methohexital, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, where precise quantification of Methohexital is required for drug metabolism studies, pharmacokinetic research, and compliance testing.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of Methohexital.
• Essential component in pharmaceutical research and development for studying the pharmacokinetics, bioavailability, and metabolic pathways of Methohexital.
• Critical for forensic and clinical toxicology laboratories to accurately identify and measure Methohexital levels in biological matrices.
• Used in doping control analysis to detect the presence of banned substances in sports.
• Supports regulatory compliance and quality assurance testing in pharmaceutical manufacturing.
• Facilitates stable isotope dilution analysis (SIDA) methods, which are considered the gold standard for accurate quantification.

Basic Information

Product Name	Methohexital-D5
CAS No.	160227-45-2
Molecular Formula	C14H13D5N2O3
Molecular Weight	267.32 g/mol (for deuterated form)
Synonyms	Methohexital-d5; 1-Methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2,2,3,3,3-pentadeuteriopropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; Brevital-d5 (deuterated); 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; Sodium Methohexital-d5 (salt form); Methylhexabital-d5; EMB-d5; Methohexitone-d5
EINECS	Contact for details

Quality Control

Every batch of Methohexital-D5 is manufactured and analyzed to meet the stringent requirements for stable isotope-labeled internal standards. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing specifications for identity, purity (by HPLC), isotopic purity, and residual solvents, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.