Description

n-α-Fmoc-n-ε-4-Methoxytrityl-L-Lysine CAS NO 159857-60-0 is a sophisticated, orthogonally protected derivative of the essential amino acid L-lysine, designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling the precise, sequential assembly of complex peptides and proteins by providing selective deprotection sites for the alpha and epsilon amine groups. It is an indispensable building block for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research, particularly for creating therapeutic peptides, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the controlled, sequential incorporation of lysine residues, allowing for the synthesis of peptides with specific side-chain modifications.
• Pharmaceutical Intermediate: Key raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs) for therapeutic applications.
• Bioconjugation and Labeling: Used to introduce functional handles (via the Mmt-protected epsilon amine) for attaching fluorophores, tags, or linkers to peptides.
• GPCR Ligand and Epitope Mapping: Essential for synthesizing peptide libraries and analogs used in drug discovery and immunological studies.
• Antibody-Drug Conjugate (ADC) Research: Serves as a linker component or a site for attaching payloads in the development of targeted cancer therapies.
• Biochemical Research: Fundamental reagent for studying protein-protein interactions, enzyme kinetics, and structural biology.

Basic Information

Item	Detail
Product Name	n-α-Fmoc-n-ε-4-Methoxytrityl-L-Lysine
CAS No.	159857-60-0
Molecular Formula	C46H42N2O6
Molecular Weight	718.84 g/mol
Synonyms	Fmoc-Lys(Mmt)-OH; Nα-Fmoc-Nε-(4-Methoxytrityl)-L-lysine; Fmoc-Lys(Mtt)-OH (common abbreviation); (2S)-6-[[Bis(4-methoxyphenyl)phenylmethoxy]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ε-(4-methoxytrityl)-L-lysine; Fmoc-Lysine(Mmt)-OH; Fmoc-Lys(MOMtr)-OH
EINECS	Contact for details

Quality Control

Our production of n-α-Fmoc-n-ε-4-Methoxytrityl-L-Lysine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.