Description

Adenosine 3',5'-Cyclic Monophosphate Acetoxymethyl Ester is a cell-permeable, hydrolyzable ester derivative of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signal transduction. This compound is crucial for researchers as it facilitates the intracellular delivery of cAMP, enabling the study of protein kinase A (PKA) pathways and other cAMP-mediated processes without disrupting the cell membrane. It is an essential biochemical tool for life science research, particularly in cell biology, pharmacology, and neuroscience, where precise manipulation of intracellular signaling is required.

Application

• Intracellular Signaling Research: Used as a cell-permeable cAMP analog to activate Protein Kinase A (PKA) and study downstream effects in various cell types.
• Neuroscience Studies: Investigates the role of cAMP in neuronal plasticity, synaptic transmission, and memory formation.
• Cardiovascular Research: Explores cAMP's effects on heart muscle contractility and ion channel regulation in cardiac myocytes.
• Metabolic Pathway Analysis: Utilized to examine cAMP-mediated regulation of glycogen, lipid, and glucose metabolism.
• Pharmacological Screening: Serves as a reference compound or tool in high-throughput assays to identify modulators of adenylate cyclase or phosphodiesterase activity.
• Cell Culture & Differentiation Studies: Applied to influence cell fate decisions, such as stem cell differentiation, through cAMP-dependent pathways.

Basic Information

Product Name	Adenosine 3',5'-Cyclic Monophosphate Acetoxymethyl Ester
CAS No.	159764-93-9
Molecular Formula	C17H23N5O8P
Molecular Weight	480.37 g/mol
Synonyms	cAMP-AM; 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphate acetoxymethyl ester; Acetoxymethyl cAMP; Cell-permeable cAMP ester; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate acetoxymethyl ester (common related compound); db-cAMP-AM; Cyclic AMP acetoxymethyl ester
EINECS	Contact for details

Quality Control

Our Adenosine 3',5'-Cyclic Monophosphate Acetoxymethyl Ester is produced under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.