Description

Mk677 CAS NO 159634-87-4 is a potent, orally active, and selective agonist of the ghrelin receptor, functioning as a growth hormone secretagogue. This compound is of significant interest for its role in stimulating the release of growth hormone and insulin-like growth factor 1 (IGF-1) from the pituitary gland. It is primarily utilized in research and development within the pharmaceutical and life science sectors for metabolic studies, age-related muscle wasting (sarcopenia), and bone density research.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the development of novel therapeutics targeting growth hormone deficiencies and metabolic disorders.
• Life Science & Biochemical Research: For in-vitro and in-vivo studies investigating the ghrelin signaling pathway, muscle protein synthesis, and metabolic regulation.
• Academic Research: Used in university and institutional labs for preclinical studies related to endocrinology, gerontology, and cachexia.
• Reference Standard Manufacturing: Serves as a high-purity certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Mk677
CAS No.	159634-87-4
Molecular Formula	C28H39N3O3S
Molecular Weight	497.69 g/mol
Synonyms	Ibutamoren; Ibutamoren Mesylate; MK-0677; MK 677; L-163,191; N-[2(R)-[[1,2-Diethylamino]carbonyl]hydroxypropyl]-L-alanyl-L-tryptophan 1-methylethyl ester; Ghrelin mimetic; Growth hormone secretagogue receptor agonist
EINECS	Contact for details

Quality Control

Our Mk677 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure it meets high-grade standards for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.