Description

Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido]Hexanoate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a sulfhydryl-reactive pyridyldithiol group. This compound is essential for creating stable, cleavable conjugates between proteins, peptides, or other biomolecules, enabling advanced research and diagnostic applications. It is a critical tool for scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and protein labeling.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for constructing cleavable linkers between monoclonal antibodies and cytotoxic payloads.
• Protein-Protein/Peptide Conjugation: Facilitates the site-specific crosslinking of different biomolecules for structural studies or to create novel bifunctional agents.
• Immobilization Chemistry: Used to attach proteins or peptides to solid supports (e.g., sensor chips, resins, nanoparticles) via a disulfide bond that can be cleaved under reducing conditions.
• Diagnostic Reagent Manufacturing: Employed in the production of enzyme-labeled antibodies and other detection conjugates for immunoassays.
• Biomolecule Labeling: Enables the introduction of tags (e.g., fluorophores, biotin) onto proteins through free thiol groups.
• Drug Delivery System Development: Used in research to create targeted delivery vehicles where the linker is designed to release the cargo in specific cellular environments.

Basic Information

Product Name	Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido]Hexanoate
CAS No.	158913-22-5
Molecular Formula	C20H24N4O5S2
Molecular Weight	464.56 g/mol
Synonyms	SPDP-Hexanoate; NHS-PDPH; 6-((3-(2-Pyridyldithio)propanamido)hexanoic acid N-hydroxysuccinimide ester; LC-SPDP; N-Succinimidyl 6-(3-(2-pyridyldithio)propanamido)hexanoate; Succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate; SMPH; N-Succinimidyl-S-(2-pyridyldithio)hexanoate
EINECS	Contact for details

Quality Control

Our Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido]Hexanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided to support your research and cGMP-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.