Description

8-Oxo-Benzylguanine is a high-purity, synthetic organic compound of significant interest in advanced pharmaceutical research and development. This specialized chemical serves as a critical building block and reference standard in the synthesis of novel therapeutic agents and biochemical probes. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in oncology, enzymology, and nucleotide analog studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted cancer therapeutics and enzyme inhibitors.
• Biochemical Research: Used as a reference standard and substrate in studies involving DNA repair enzymes, such as O6-alkylguanine-DNA alkyltransferase (AGT).
• Probe Development: Employed in the design and development of fluorescent or affinity probes for studying specific enzyme activity and cellular pathways.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.
• Process Development & Scale-up: Serves as a critical material for process optimization and analytical method development during drug candidate scale-up.

Basic Information

Product Name	8-Oxo-Benzylguanine
CAS No.	158754-46-2
Molecular Formula	C12H9N5O2
Molecular Weight	255.23 g/mol
Synonyms	O6-Benzyl-8-oxoguanine; 8-Oxo-O6-benzylguanine; 2-Amino-6-(benzyloxy)-7,9-dihydro-1H-purin-8-one; 6-(Benzyloxy)-2-amino-7,9-dihydro-8H-purin-8-one; BG; O6-BG; O6-Benzylguanine derivative
EINECS	Contact for details

Quality Control

Our 8-Oxo-Benzylguanine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.