Description

O1-(Dimethoxytrityl)Tetraethylene Glycol is a high-purity, monodisperse polyethylene glycol derivative featuring a dimethoxytrityl (DMT) protecting group at one terminus. This compound is critical for providing a precisely controlled, hydrophilic spacer arm in the synthesis of oligonucleotides and other complex biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, high-quality building blocks for solid-phase synthesis and bioconjugation.

Application

• Oligonucleotide Synthesis: Serves as a key hydrophilic spacer or linker in the solid-phase synthesis of modified DNA/RNA, antisense oligonucleotides, and aptamers.
• Bioconjugation & PEGylation: Acts as a functionalized PEG derivative for attaching drugs, probes, or other molecules to biomolecules like peptides, proteins, or nanoparticles.
• Probe & Diagnostic Reagent Manufacturing: Used in the production of labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Solid Support Functionalization: Employed to introduce a reactive, protected hydroxyl group onto resins and other solid supports for combinatorial chemistry.
• Building Block for Specialty Polymers: Functions as a monomer or initiator in the synthesis of tailored, functional polyethylene glycol-based polymers and dendrimers.

Basic Information

Product Name	O1-(Dimethoxytrityl)Tetraethylene Glycol
CAS No.	158041-84-0
Molecular Formula	C31H40O7
Molecular Weight	524.65 g/mol
Synonyms	DMT-Tetraethylene Glycol; 2-[2-[2-[2-[Bis(4-methoxyphenyl)phenylmethoxy]ethoxy]ethoxy]ethoxy]ethanol; Tetraethylene Glycol Monodimethoxytrityl Ether; 1-[Bis(4-methoxyphenyl)phenylmethyl]-3,6,9,12-tetraoxatetradecan-14-ol; DMT-PEG4-OH; Monomethoxytrityl Tetraethylene Glycol (common misnomer); 4,4'-Dimethoxytrityl Tetraethylene Glycol; DMT-PEG4
EINECS	Contact for details

Quality Control

Our O1-(Dimethoxytrityl)Tetraethylene Glycol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical and biotech research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with internal quality standards and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.