Description

6-Maleimido-1-Hexanol CAS NO 157503-18-9 is a heterobifunctional crosslinking agent featuring a maleimide group for thiol conjugation and a terminal hydroxyl group for further functionalization. This compound is essential for creating stable, site-specific bioconjugates in advanced research and therapeutic development. It is primarily utilized by scientists and manufacturers in the fields of biopharmaceuticals, diagnostics, and materials science for antibody-drug conjugate (ADC) development, protein labeling, and surface modification.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable, or non-cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Protein and Peptide Modification: Site-specific conjugation of peptides, proteins, or enzymes via cysteine residues for labeling, immobilization, or creating fusion constructs.
• Surface Functionalization: Modification of nanoparticles, biosensors, or chromatographic media to introduce reactive groups for subsequent biomolecule attachment.
• Polymer Chemistry: Serving as a monomer or crosslinker in the synthesis of functionalized hydrogels, smart materials, and drug delivery systems.
• Diagnostic Reagent Synthesis: Conjugation of detection probes (e.g., fluorophores, enzymes) to antibodies or other targeting molecules for immunoassays.
• Bioconjugation Research: A versatile tool in academic and industrial R&D for exploring novel conjugation strategies and biomaterial engineering.

Basic Information

Product Name	6-Maleimido-1-Hexanol
CAS No.	157503-18-9
Molecular Formula	C10H15NO3
Molecular Weight	197.23 g/mol
Synonyms	6-Maleimidocaproyl Alcohol; 1-Hexanol, 6-maleimido-; 6-(Maleimido)hexan-1-ol; Maleimide-C6-OH; N-(6-Hydroxyhexyl)maleimide; 6-Hydroxyhexyl maleimide; 6-Maleimidohexanol; EMCS Alcohol Analog
EINECS	Contact for details

Quality Control

Our 6-Maleimido-1-Hexanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.