Description

31-Homorifamycin W is a semi-synthetic derivative of the rifamycin class of antibiotics, representing a key intermediate in the development of novel antimicrobial agents. Its primary value lies in its structural modification, which is engineered to enhance biological activity and overcome resistance mechanisms prevalent in pathogenic bacteria. This compound is essential for pharmaceutical R&D teams and fine chemical manufacturers focused on creating next-generation antibiotics and conducting advanced structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of novel rifamycin-based antibiotics targeting resistant bacterial strains.
• Antimicrobial Research: Used in biochemical and microbiological research to study mechanisms of action against RNA polymerase in bacteria.
• Structure-Activity Relationship (SAR) Studies: Serves as a core scaffold for medicinal chemists to develop analogs with improved potency, spectrum, and pharmacokinetic profiles.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and compound identification.
• Bioconjugation Studies: Utilized in developing targeted drug delivery systems or antibody-drug conjugates (ADCs) due to its modifiable functional groups.

Basic Information

Product Name	31-Homorifamycin W
CAS No.	157049-51-9
Molecular Formula	C38H47NO13
Molecular Weight	725.78 g/mol
Synonyms	(31S)-31-Homorifamycin W; 31-Homo-rifamycin W; Rifamycin W, 31-homo-; 31-Homorifamycin; Rifamycin derivative 31-homo; Antibiotic GE 2270 derivative; Ansamycin antibiotic intermediate
EINECS	Contact for details

Quality Control

Our 31-Homorifamycin W is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere (e.g., nitrogen or argon) to maintain stability.

Specification

Item	Specification
Appearance	Yellow to Orange Powder
Identification (HPLC)	Conforms to Reference Standard
Identification (IR)	Conforms to Structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.