Description

Terpendole C is a complex indole-diterpene alkaloid of significant interest in biochemical research and development. This compound matters as a potent and specific inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme in cellular cholesterol esterification. It is primarily needed by researchers in the pharmaceutical and biotechnology sectors for studying lipid metabolism, atherosclerosis, and for use as a critical reference standard in analytical laboratories.

Application

• Pharmacological Research: Used as a selective ACAT inhibitor to study cholesterol absorption, storage, and metabolism in cell-based assays and animal models.
• Drug Discovery & Development: Serves as a lead compound or biochemical tool for developing novel therapeutics targeting atherosclerosis and metabolic disorders.
• Analytical Reference Standard: Employed as a high-purity certified standard for quality control and method validation in HPLC, LC-MS, and other analytical techniques.
• Biochemical Pathway Studies: A key reagent for investigating the role of ACAT in lipid droplet formation, foam cell development, and related cellular processes.
• Academic Research: Utilized in university and institutional labs for fundamental research in biochemistry, cell biology, and medicinal chemistry.

Basic Information

Product Name	Terpendole C
CAS No.	156967-65-6
Molecular Formula	C29H35NO5
Molecular Weight	477.60 g/mol
Synonyms	Terpendole C; ACAT Inhibitor Terpendole C; 3-Desacetyl-3-hydroxyterpendole C; 19-O-Acetylterpendole C (related isomer); Indole-diterpene alkaloid; ACAT inhibitor 156967-65-6; (1R,2S,5S,7R,10R,11S,14S,15R,17S)-5,17-Dihydroxy-14-(1H-indol-3-ylmethyl)-4,4,7,10,12,12,15-heptamethyl-3,8,16-trioxo-2,13-dioxatetracyclo[11.3.1.12,5.01,10]heptadec-6-en-11-yl acetate
EINECS	Contact for details

Quality Control

Our Terpendole C is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analysis including HPLC purity determination, structural confirmation (NMR, MS), and identity verification. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.