Description

Ac-Lys-Amc CAS NO 156661-42-6 is a specialized fluorogenic peptide substrate designed for sensitive enzymatic assays. This compound is critical for researchers and quality control laboratories requiring precise detection and quantification of protease activity. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for drug discovery, biochemical pathway analysis, and diagnostic development.

Application

• Protease Activity Assays: Used as a specific fluorogenic substrate for measuring the activity of lysine-specific proteases and related enzymes in high-throughput screening (HTS).
• Biochemical Research: Essential tool for studying enzyme kinetics, inhibition mechanisms, and substrate specificity in academic and industrial R&D settings.
• Pharmaceutical Development: Employed in the discovery and optimization of novel therapeutic protease inhibitors by monitoring enzymatic cleavage.
• Diagnostic Reagent Manufacturing: Serves as a key component in the formulation of diagnostic kits for detecting specific protease biomarkers.
• Quality Control Testing: Applied in biopharmaceutical manufacturing to monitor and validate the purity and activity of enzyme-based products.

Basic Information

Product Name	Ac-Lys-Amc
CAS No.	156661-42-6
Molecular Formula	C18H24N4O4
Molecular Weight	360.41 g/mol
Synonyms	Acetyl-L-Lysine 7-Amido-4-Methylcoumarin; Nα-Acetyl-L-lysine 7-amido-4-methylcoumarin; Ac-Lys-AMC; Ac-Lys-AMC substrate; N-Acetyl-L-lysine-7-amido-4-methylcoumarin; L-Lysine, N2-acetyl-, 1-(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-yl) ester; Fluorogenic Lysine Substrate
EINECS	Contact for details

Quality Control

Our Ac-Lys-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.