Description

7-Azabenzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate is a high-performance coupling reagent widely used in modern peptide synthesis. This compound matters because it offers superior efficiency and reduced racemization compared to traditional agents, enabling the production of high-purity peptides. It is primarily needed by pharmaceutical R&D teams, biotech companies, and fine chemical manufacturers engaged in the synthesis of complex peptides, peptidomimetics, and other sensitive amide bonds.

Application

• Peptide Synthesis: As a key coupling reagent for solid-phase and solution-phase peptide synthesis, minimizing epimerization.
• Pharmaceutical Intermediates: In the production of active pharmaceutical ingredients (APIs) and complex drug candidates requiring amide bond formation.
• Bioconjugation: For linking peptides to other molecules, proteins, or surfaces in drug delivery system development.
• Combinatorial Chemistry: Used in high-throughput screening libraries for drug discovery applications.
• Academic & Industrial Research: A critical tool in organic and medicinal chemistry laboratories for constructing challenging amide linkages.
• Fine Chemical Production: In the synthesis of specialty chemicals, agrochemicals, and advanced materials where high-yield, clean coupling is required.

Basic Information

Product Name	7-Azabenzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate
CAS No.	156311-85-2
Molecular Formula	C13H22F6N7OP2
Molecular Weight	488.30 g/mol
Synonyms	HATU; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate; 1-(Dimethylamino)-(1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene)dimethylaminium hexafluorophosphate N-oxide; O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; Azabenzotriazole Tetramethyl Uronium Hexafluorophosphate; Coupling Reagent HATU; Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium
EINECS	Contact for details

Quality Control

Our 7-Azabenzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in polar aprotic solvents (DMF, DMSO, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.