Description

(2-(Trimethylammonium)Ethyl)Methanethiosulfonate is a specialized, high-purity chemical reagent widely used in advanced biochemical and bioconjugation research. Its primary value lies in its role as a highly effective sulfhydryl-reactive crosslinking agent, enabling precise protein modification and labeling. This compound is essential for researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and diagnostic assay formulation, where reliable and specific conjugation chemistry is critical.

Application

• Bioconjugation Reagent: A key intermediate for modifying proteins, peptides, and antibodies by selectively reacting with free thiol (-SH) groups.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs for targeted cancer therapies.
• Protein Labeling & Immobilization: Facilitates the attachment of fluorescent dyes, enzymes, or other probes to biomolecules for diagnostic and research applications.
• Surface Functionalization: Employed to create thiol-reactive surfaces on biosensors, microarrays, and chromatography media.
• Crosslinking Studies: Utilized in structural biology to investigate protein-protein interactions and complex formation.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of more complex therapeutic agents.

Basic Information

Product Name	(2-(Trimethylammonium)Ethyl)Methanethiosulfonate
CAS No.	155450-08-1
Molecular Formula	C6H15NO2S2+
Molecular Weight	197.32 g/mol
Synonyms	MTSET; (2-Trimethylammoniumethyl) Methanethiosulfonate Bromide; [2-(Trimethylazaniumyl)ethyl] methanesulfonothioate; Ammonium, (2-((methylsulfonyl)thio)ethyl)trimethyl-, bromide; Methanethiosulfonic acid S-[2-(trimethylammonio)ethyl] ester; Trimethyl(2-((methylsulfonyl)thio)ethyl)ammonium; Thiol-reactive crosslinker MTSET
EINECS	Contact for details

Quality Control

Our (2-(Trimethylammonium)Ethyl)Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping the product desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.