Description

n-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid 1,5-Dimethyl Ester is a high-purity, non-classical folate analog and a key synthetic intermediate in pharmaceutical research and development. This compound is of significant commercial importance due to its role as a precursor in the synthesis of novel antifolate drugs, which target critical enzymes like thymidylate synthase and glycinamide ribonucleotide formyltransferase. It is primarily needed by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in the development of chemotherapeutic agents, enzyme inhibitors, and targeted therapies for oncology and autoimmune diseases.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel antifolate chemotherapeutic agents targeting thymidylate synthase (TS).
• Oncology Research: Used in the development and study of targeted cancer therapies, particularly for solid tumors.
• Enzyme Inhibition Studies: Serves as a tool compound for investigating the mechanism of folate-dependent enzymes like glycinamide ribonucleotide formyltransferase (GARFTase).
• Process Chemistry & Scale-up: Employed in the optimization of synthetic routes for Good Manufacturing Practice (GMP) production of active pharmaceutical ingredients (APIs).
• Biochemical Assay Development: Utilized as a standard or reference material in high-throughput screening (HTS) and biochemical assays.
• Academic & Contract Research: Key material for fundamental research in medicinal chemistry and drug discovery programs within universities and CROs.

Basic Information

Product Name	n-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid 1,5-Dimethyl Ester
CAS No.	155405-81-5
Molecular Formula	C22H25N5O6
Molecular Weight	455.47 g/mol
Synonyms	L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 1,5-dimethyl ester; AG 2034; AG-2034; AG2034; 5,10-Dideazatetrahydrofolate dimethyl ester; DDATHF dimethyl ester; Lometrexol dimethyl ester intermediate; Pyrrolo[2,3-d]pyrimidine folate analog intermediate
EINECS	Contact for details

Quality Control

Our n-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid 1,5-Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.