Description

Pemetrexed CAS NO 155405-79-1 is a potent antifolate chemotherapeutic agent that functions as a multi-targeted enzyme inhibitor. Its primary value lies in its ability to disrupt folate-dependent metabolic processes essential for cancer cell proliferation, making it a cornerstone in modern oncology treatment regimens. This high-purity active pharmaceutical ingredient (API) is critically needed by pharmaceutical manufacturers and research institutions for the formulation of injectable drugs targeting non-small cell lung cancer and malignant pleural mesothelioma.

Application

• Primary API in the manufacture of Pemetrexed disodium for injectable chemotherapy formulations.
• Key ingredient for oncology drug development and clinical trial materials.
• Used in pharmaceutical research for studying antifolate mechanisms and combination therapies.
• Essential for producing generic versions of leading antineoplastic medications.
• Reference standard for quality control and analytical method development in pharmaceutical labs.
• Intermediate in the synthesis of more complex targeted cancer therapeutics.

Basic Information

Product Name	Pemetrexed
CAS No.	155405-79-1
Molecular Formula	C20H21N5O6
Molecular Weight	427.41 g/mol
Synonyms	LY231514; Alimta (brand name intermediate); N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid; Pemetrexed Acid; MTA (Multi-Targeted Antifolate); NSC-698037; Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, L-
EINECS	Contact for details

Quality Control

Our Pemetrexed is manufactured under strict cGMP conditions, ensuring it meets the stringent requirements for pharmaceutical active ingredients. Quality is verified through a comprehensive battery of tests including HPLC assay, related substance profiling, and residual solvent analysis. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with in-house specifications aligned with major pharmacopeial standards. Our quality management system is designed to guarantee batch-to-batch consistency and traceability for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.