Description

Norchloroepibatidine is a potent and selective nicotinic acetylcholine receptor (nAChR) ligand, derived from the natural alkaloid epibatidine. This compound is of significant interest in advanced pharmacological research and neurochemical studies due to its high binding affinity and specificity. It serves as a critical tool for researchers and pharmaceutical developers in the fields of neuroscience, medicinal chemistry, and drug discovery, particularly for investigating receptor function and developing novel therapeutic agents.

Application

• Neuroscience Research: As a high-affinity ligand for studying the structure and function of neuronal nicotinic acetylcholine receptors.
• Medicinal Chemistry: A key intermediate or reference standard in the design and synthesis of novel analgesics and neurological drugs.
• Pharmacological Screening: Used in in vitro and in vivo assays to evaluate the activity and selectivity of potential new drug candidates targeting nAChRs.
• Biochemical Tool: Employed in receptor binding studies and autoradiography to map receptor distribution in tissues.
• Reference Standard: Serves as a certified analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Institutional Research: Fundamental research into pain pathways, addiction mechanisms, and cognitive disorders.

Basic Information

Product Name	Norchloroepibatidine
CAS No.	155322-26-2
Molecular Formula	C11H12ClN3
Molecular Weight	221.69 g/mol
Synonyms	(±)-Norchloroepibatidine; 2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane; 2-(6-Chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane; exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane; Norchloroepibatidine (racemic); 7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (±)-; NSC 324622
EINECS	Contact for details

Quality Control

Our Norchloroepibatidine is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term stability, consider storage under inert atmosphere at -20°C. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.