Description

Peg6-Tos CAS NO 155130-15-7 is a specialized polyethylene glycol derivative functionalized with a tosylate (p-toluenesulfonate) group at one terminus. This bifunctional molecule is a critical intermediate in organic synthesis and bioconjugation, serving as a versatile linker for attaching various functional groups, ligands, or probes to target molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable building blocks for creating complex molecular architectures, such as antibody-drug conjugates (ADCs), PEGylated therapeutics, and functional polymers.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly for introducing hydrophilic PEG spacers.
• Bioconjugation & ADC Development: Used as a heterobifunctional crosslinker to connect drugs, toxins, or imaging agents to antibodies, proteins, or peptides in the production of antibody-drug conjugates (ADCs) and other bioconjugates.
• Polymer & Materials Science: Acts as a functional initiator or monomer in the synthesis of tailored block copolymers, hydrogels, and surface-modifying agents.
• Prodrug Synthesis: Facilitates the creation of prodrugs by linking therapeutic agents to a PEG chain via a cleavable bond, enhancing solubility and pharmacokinetics.
• Chemical Biology & Proteomics: Employed in labeling and modifying biomolecules for research applications, including fluorescence tagging and affinity purification.
• Surface Functionalization: Used to modify nanoparticles, sensors, and diagnostic devices to improve biocompatibility and introduce specific reactive sites.

Basic Information

Product Name	Peg6-Tos
CAS No.	155130-15-7
Molecular Formula	C21H36O9S
Molecular Weight	464.57 g/mol
Synonyms	Hexaethylene Glycol Monotosylate; PEG6 Tosylate; 2-[2-[2-[2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 4-Methylbenzenesulfonic Acid 2-[2-[2-[2-[2-[2-Hydroxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl Ester; 19-Oxa-3,6,9,12,15-pentaoxahenicosan-1-yl 4-methylbenzenesulfonate; mPEG6-OTs; Tos-PEG6-OH; Polyethylene Glycol Monomethyl Ether 6-Tosylate (approx. MW)
EINECS	Contact for details

Quality Control

Our Peg6-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical and biotech applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.