Description

2',3'-Dideoxyguanosine-5'-o-(1-Thiotriphosphate) Sodium Salt is a chemically modified nucleotide analog where a sulfur atom replaces one of the non-bridging oxygen atoms in the triphosphate moiety. This compound is critical for research in molecular biology and enzymology, particularly for studying nucleic acid metabolism and polymerase mechanisms. It is primarily utilized by biotech and pharmaceutical R&D teams, as well as academic researchers, for applications requiring nucleotide analogs with altered biochemical properties.

Application

• Enzymology Studies: Used as a substrate analog to investigate the kinetics and mechanisms of DNA and RNA polymerases, reverse transcriptases, and other nucleotide-processing enzymes.
• Antiviral Research: Serves as a biochemical tool in the study of nucleoside reverse transcriptase inhibitors (NRTIs) and the development of antiviral therapies.
• Metabolic Pathway Analysis: Employed in tracing and analyzing nucleotide salvage and incorporation pathways within cells.
• Biochemical Assay Development: Acts as a key reagent in the development of high-throughput screening assays for enzyme activity and inhibitor discovery.
• Structural Biology: Used in X-ray crystallography and NMR studies to understand enzyme-substrate interactions at the atomic level.
• Chain Termination Studies: Investigated for its potential role in nucleic acid sequencing techniques and understanding chain termination events.

Basic Information

Product Name	2',3'-Dideoxyguanosine-5'-o-(1-Thiotriphosphate) Sodium Salt
CAS No.	154771-50-3
Molecular Formula	C10H13N5O11P3S · xNa+
Molecular Weight	Contact for details
Synonyms	2',3'-Dideoxyguanosine 5'-(1-thiotriphosphate) sodium salt; ddGTPαS sodium salt; Guanosine-5'-[(α-thio)]-triphosphate, 2',3'-dideoxy-, sodium salt; 2',3'-Dideoxy-GTPαS; Thio-dideoxyguanosine triphosphate sodium salt; 2',3'-ddGTPαS Na; 5'-O-[1-Thiotriphosphate]-2',3'-dideoxyguanosine sodium salt
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyguanosine-5'-o-(1-Thiotriphosphate) Sodium Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for life science research. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.