Description

2',3'-Dideoxycytidine-5'-o-(1-Thiotriphosphate) Sodium Salt is a chemically modified nucleoside triphosphate analog, specifically engineered with a sulfur-for-oxygen substitution in the α-phosphate position. This critical modification makes it a valuable non-hydrolyzable substrate and inhibitor for enzymatic studies, particularly in molecular biology and virology research. It is essential for researchers and manufacturers developing antiviral agents, studying DNA/RNA polymerases, and creating diagnostic probes.

Application

• Enzymology Research: Used as a non-hydrolyzable substrate or competitive inhibitor in mechanistic studies of DNA and RNA polymerases, reverse transcriptases, and other nucleotide-dependent enzymes.
• Antiviral Drug Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the research and synthesis of nucleoside analog-based antiviral therapeutics.
• Molecular Biology: Employed in the study of nucleic acid metabolism, enzyme kinetics, and the development of novel biochemical assays.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled or modified nucleotides for diagnostic kits and research tools.
• Biochemical Tool Compound: Acts as a specific reagent to probe nucleotide-binding sites and catalytic mechanisms in structural biology.

Basic Information

Product Name	2',3'-Dideoxycytidine-5'-o-(1-Thiotriphosphate) Sodium Salt
CAS No.	154771-49-0
Molecular Formula	C9H13N3O11P3S · xNa
Molecular Weight	Contact for details
Synonyms	2',3'-Dideoxycytidine 5'-(1-thiotriphosphate), sodium salt; ddCTPαS, Sodium Salt; 5'-O-[Hydroxy(phosphonooxy)phosphinothioyl]-2',3'-dideoxycytidine sodium salt; 2',3'-Dideoxycytidine-5'-(α-thiotriphosphate) trisodium salt; Thio-dideoxycytidine triphosphate; Non-hydrolyzable ddCTP; CAS 154771-49-0
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxycytidine-5'-o-(1-Thiotriphosphate) Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.