Description

H-Asp-Pna Hcl CAS NO 154564-03-1 is a high-purity, protected aspartic acid derivative, specifically the hydrochloride salt of N-α-Boc-L-aspartic acid 4-nitroanilide. This compound serves as a critical building block (synthon) in sophisticated organic synthesis, particularly in peptide chemistry and medicinal chemistry research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for developing novel therapeutic agents and biochemical tools.

Application

• Peptide Synthesis: Used as a protected aspartic acid precursor for the solid-phase and solution-phase synthesis of complex peptides.
• Medicinal Chemistry Research: Serves as a key intermediate in the design and development of protease inhibitors and other biologically active molecules.
• Bioconjugation: Acts as a specialty linker or spacer molecule in the preparation of peptide-protein conjugates and other bioconjugates.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes (ABPs) and other diagnostic tools for studying enzyme function.
• Custom Synthesis: A vital starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry and biochemistry.

Basic Information

Product Name	H-Asp-Pna Hcl
CAS No.	154564-03-1
Molecular Formula	C15H20N4O7 • HCl
Molecular Weight	428.81 g/mol
Synonyms	Boc-Asp-pNA HCl; N-α-(tert-Butoxycarbonyl)-L-aspartic acid 4-nitroanilide hydrochloride; Boc-L-Aspartic acid 4-nitroanilide HCl; Boc-Asp-OpNA•HCl; (2S)-4-[(4-Nitrophenyl)amino]-2-{[(2-methylpropan-2-yl)oxycarbonyl]amino}-4-oxobutanoic acid hydrochloride; N-Boc-L-aspartic acid 4-nitroanilide hydrochloride; Aspartic acid derivative Boc-Asp-pNA•HCl; L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our H-Asp-Pna Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific optical rotation measurement. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.