Description

9-Hydroxy-21-(4-Azidobenzoyloxy)-9-Epiryanodine is a chemically modified derivative of the natural product ryanodine, engineered as a critical tool compound for advanced biochemical research. This molecule matters for its role as a potent and specific modulator of ryanodine receptors (RyRs), which are pivotal calcium release channels in cellular physiology. It is primarily needed by researchers in pharmacology, neurobiology, and cardiovascular science for probing calcium signaling pathways, studying muscle contraction mechanisms, and developing novel therapeutic agents.

Application

• Biochemical Research: A key tool for studying the structure, function, and pharmacology of ryanodine receptor (RyR) calcium channels in vitro.
• Pharmacological Studies: Used to investigate calcium signaling dysregulation in disease models, including cardiac arrhythmias and muscular disorders.
• Neuroscience Research: Employed in synaptic plasticity studies to understand the role of intracellular calcium stores in neuronal communication and memory formation.
• Drug Discovery & Development: Serves as a reference standard and a molecular probe for screening and validating new compounds targeting RyR channels.
• Cellular Physiology: Utilized to manipulate intracellular calcium levels in muscle cells (skeletal and cardiac) to study excitation-contraction coupling.
• Photoreactive Probing: The azido group enables photoaffinity labeling studies to map the binding sites of ryanodine analogs on receptor proteins.

Basic Information

Product Name	9-Hydroxy-21-(4-Azidobenzoyloxy)-9-Epiryanodine
CAS No.	154504-97-9
Molecular Formula	C₃₄H₃₅N₅O₈
Molecular Weight	641.67 g/mol
Synonyms	9-Hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine; 9-epi-21-O-(4-azidobenzoyl)ryanodol; 21-(4-Azidobenzoyloxy)-9-epiryanodine; Azido-modified ryanodine derivative; RyR photoaffinity ligand; Ryanodine receptor probe; Calcium channel research chemical
EINECS	Contact for details

Quality Control

Our high-purity biochemical reagents undergo rigorous quality testing to ensure batch-to-batch consistency and reliability for sensitive research applications. Standard quality assurance includes verification of identity, purity, and stability. Certificates of Analysis (COA) detailing comprehensive analytical results from techniques such as HPLC, NMR, and mass spectrometry are available upon request to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This compound is light-sensitive and should be handled under appropriate conditions to maintain its chemical integrity and photoreactive functionality. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.