Description

Poly(Ethylene Oxide) 4-Arm Succinimid& CAS NO 154467-38-6 is a multi-arm, functionalized polyethylene glycol (PEG) derivative featuring reactive succinimidyl ester termini. This compound matters for its ability to create stable amide bonds with primary amines, making it a critical building block for advanced bioconjugation and crosslinking applications. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing drug delivery systems, hydrogels, and functionalized surfaces.

Application

• Bioconjugation Linker: For coupling peptides, proteins, antibodies, or other amine-containing biomolecules to polymers, surfaces, or nanoparticles.
• PEGylation Reagent: Used to create multi-arm PEGylated therapeutics to enhance solubility, stability, and circulation time of drugs.
• Hydrogel Formation: Serves as a multi-functional crosslinker for creating biocompatible PEG-based hydrogels for tissue engineering and 3D cell culture.
• Surface Functionalization: Enables the modification of amine-reactive surfaces with a dense, hydrophilic PEG layer to reduce non-specific binding (e.g., in biosensors).
• Dendrimer and Polymer Synthesis: Acts as a core molecule for constructing star-shaped or branched polymeric architectures.
• Diagnostic Reagent Preparation: Used in the development of labeled probes and assay components where stable linkage is required.

Basic Information

Product Name	Poly(Ethylene Oxide) 4-Arm Succinimid& CAS NO 154467-38-6
CAS No.	154467-38-6
Molecular Formula	Contact for details
Molecular Weight	Variable (based on PEG arm length)
Synonyms	4-Arm PEG-Succinimidyl Succinate; 4-Arm PEG-SS; Tetra-Arm PEG NHS Ester; Star-PEG NHS Ester; Poly(ethylene glycol) tetra(succinimidyl succinate); PEG4-SG; Succinimidyl ester terminated 4-arm polyethylene glycol; Multi-arm PEG-NHS
EINECS	Contact for details

Quality Control

Our Poly(Ethylene Oxide) 4-Arm Succinimid& CAS NO 154467-38-6 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure consistency in functionality, purity, and molecular weight distribution. Certificates of Analysis (COA) detailing specifications such as NHS ester content, degree of substitution, and purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis of the active ester groups.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Functional Group	Succinimidyl Ester (NHS Ester)
Number of Arms	4
PEG Average Molecular Weight (per arm)	Specified (e.g., 2k, 5k, 10k, 20k Da)
Substitution Degree	>95%
Purity (HPLC)	>95%
Solubility	Soluble in DMF, DMSO, acetonitrile; insoluble in water (reacts)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.