Description

22-Dehydro-1,25-Dihydroxy-24-Dihomovitamin D3 is a high-purity, synthetic vitamin D analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its specific structural modifications, which are critical for studying metabolic pathways and receptor interactions related to calcium homeostasis and cellular differentiation. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of novel therapeutics and biochemical probes. Our supply is characterized by stringent quality control, ensuring reliability for sensitive applications.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Biochemical Research: Used as a key intermediate or tool compound in metabolic studies, investigating the structure-activity relationships (SAR) of vitamin D analogs.
• Drug Discovery & Development: Acts as a precursor or active pharmaceutical ingredient (API) intermediate in the synthesis of novel therapeutic agents targeting bone disorders, immune modulation, and dermatological conditions.
• Academic Research: Employed in university and institutional labs for fundamental studies on nuclear receptor (VDR) activation, gene expression, and cell proliferation mechanisms.
• Diagnostic Kit Development: Utilized in the formulation of calibration standards and controls for immunoassays and LC-MS/MS kits measuring vitamin D metabolites.

Basic Information

Product Name	22-Dehydro-1,25-Dihydroxy-24-Dihomovitamin D3
CAS No.	154356-84-0
Molecular Formula	C₂₉H₄₄O₃
Molecular Weight	440.66 g/mol
Synonyms	1,25-Dihydroxy-22-dehydro-24-dihomovitamin D3; 1,25-Dihydroxy-22-dehydro-24-dihomo-cholecalciferol; 24-Dihomo-22-dehydro-1,25-dihydroxyvitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19),22-tetraene-1,3,25-triol; 22-Dehydro-1α,25-dihydroxy-24-dihomovitamin D₃; Vitamin D analog 154356-84-0
EINECS	Contact for details

Quality Control

Every batch of 22-Dehydro-1,25-Dihydroxy-24-Dihomovitamin D3 is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced techniques like HPLC and NMR. Our quality commitment ensures the material meets the exacting standards required for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.