Description

19-Hydroxycortisol is a significant steroid metabolite and a key intermediate in the biosynthesis and metabolism of cortisol. This compound is essential for research into adrenal function, steroidogenic pathways, and endocrine disorders. It is primarily utilized by pharmaceutical R&D laboratories, diagnostic manufacturers, and academic institutions focused on endocrinology and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of cortisol and related steroid metabolites in biological samples via LC-MS/MS or HPLC.
• Biochemical Research: Serves as a critical intermediate for studying the 11β-hydroxysteroid dehydrogenase and cytochrome P450 enzyme pathways involved in glucocorticoid metabolism.
• Diagnostic Kit Development: Employed in the calibration and validation of immunoassays and clinical test kits designed to measure adrenal cortex function and diagnose conditions like Cushing's syndrome or adrenal insufficiency.
• Metabolite Profiling: A vital analyte in metabolomics studies aiming to understand steroid hormone imbalances and their correlation with various physiological and pathological states.

Basic Information

Product Name	19-Hydroxycortisol
CAS No.	154032-37-8
Molecular Formula	C₂₁H₃₀O₆
Molecular Weight	378.46 g/mol
Synonyms	11β,17α,19-Trihydroxy-4-pregnene-3,20-dione; 19-Hydroxycortisone; 19-OH-Cortisol; 19-Hydroxyhydrocortisone; 19-Hydroxy-11-deoxycortisol; 19-Hydroxy Reichstein's Substance S; 19-Hydroxy Compound S
EINECS	Contact for details

Quality Control

Our 19-Hydroxycortisol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the stringent requirements for research and diagnostic use. A detailed Certificate of Analysis (COA) providing batch-specific results is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.