Description

8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphothioate, Rp-Isomer Triethylammonium Salt CAS NO 153660-04-9 is a high-purity, biologically active nucleotide analog specifically engineered as a potent and selective inhibitor of cyclic GMP-dependent protein kinase (PKG). This compound is critical for researchers and developers in life sciences, providing a powerful tool for modulating intracellular signaling pathways. It is essential for advanced biochemical research, drug discovery programs, and the development of targeted therapeutic agents.

Application

• Biochemical Research: A key tool for studying the role of cGMP and PKG in cellular signaling, signal transduction, and second messenger systems.
• Pharmaceutical R&D: Used in high-throughput screening and target validation for drug discovery programs focused on cardiovascular, neurological, and inflammatory diseases.
• Cell Biology Studies: Employed to investigate cellular processes such as smooth muscle relaxation, platelet aggregation, and neuronal plasticity.
• Enzyme Inhibition Studies: Serves as a stable, hydrolysis-resistant analog to probe the specificity and mechanism of phosphodiesterases and kinases.
• Diagnostic Development: Potential use in developing assays and kits for research and clinical diagnostics related to cGMP pathways.

Basic Information

Product Name	8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphothioate, Rp-Isomer Triethylammonium Salt
CAS No.	153660-04-9
Molecular Formula	C₂₃H₃₂ClN₆O₁₀P₂S₂
Molecular Weight	705.09 g/mol
Synonyms	Rp-8-(4-Chlorophenylthio)-cGMPS triethylammonium salt; Rp-8-pCPT-cGMPS; PKG Inhibitor Rp-8-pCPT-cGMPS; Guanosine 3',5'-cyclic monophosphorothioate, 8-[(4-chlorophenyl)thio]-, Rp-isomer, triethylammonium salt; 8-(4-Chlorophenylthio)-cGMPS, Rp-isomer; Rp-8-CPT-cGMPS; cGMP-dependent protein kinase inhibitor Rp-8-pCPT-cGMPS
EINECS	Contact for details

Quality Control

Our 8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphothioate, Rp-Isomer is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the product meets the high standards required for pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.