Description

1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside derivative, specifically a protected thymidine analog, which serves as a critical building block in oligonucleotide synthesis. Its primary value lies in enabling the precise, automated construction of DNA and RNA sequences for research and therapeutic development. This compound is essential for pharmaceutical R&D, academic institutions, and biotechnology companies engaged in antisense therapy, siRNA development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for targeted gene silencing therapies.
• siRNA and miRNA Synthesis: Critical for manufacturing small interfering RNA (siRNA) and microRNA (miRNA) for RNA interference (RNAi) applications.
• Molecular Probes and Primers: Enables the creation of labeled probes and primers for PCR, sequencing, and diagnostic assays.
• Therapeutic Nucleoside Analogs: Serves as an intermediate in the synthesis of novel nucleoside-based antiviral or anticancer agents.
• Academic and Industrial Research: Used in biochemistry and molecular biology labs for studying nucleic acid structure, function, and interactions.

Basic Information

Product Name	1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	153631-19-7
Molecular Formula	C32H34N2O8
Molecular Weight	574.62 g/mol
Synonyms	5'-O-DMT-2'-O-Methyluridine; 2'-O-Methyl-5'-O-(4,4'-dimethoxytrityl)uridine; 5'-O-(Bis(4-methoxyphenyl)phenylmethyl)-2'-O-methyluridine; DMT-2'-O-Methyluridine; 1-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; Protected 2'-O-Methyluridine; Thymidine, 2'-O-methyl-, 5'-O-(4,4'-dimethoxytrityl)-; Nucleoside building block for oligonucleotide synthesis
EINECS	Contact for details

Quality Control

Our 1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.