Description

Plevitrexed CAS NO 153538-08-0 is a potent and selective thymidylate synthase inhibitor, representing a significant class of antifolate compounds. This high-purity active pharmaceutical ingredient (API) is critical for advancing targeted cancer therapies and pharmaceutical research. It is primarily utilized by pharmaceutical manufacturers, biotechnology companies, and advanced research institutions engaged in oncology drug development and clinical studies.

Application

• Oncology Drug Development: As a key active pharmaceutical ingredient (API) in the formulation of novel chemotherapeutic agents targeting thymidylate synthase.
• Pharmaceutical Research: For preclinical and clinical studies investigating the efficacy and mechanisms of antifolate compounds in various cancer models.
• Biochemical Research: As a specific inhibitor in enzymatic studies to understand folate metabolism and nucleotide biosynthesis pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Formulation Studies: Used in the development of stable and bioavailable dosage forms, including injectables and other delivery systems.
• Mechanism of Action Studies: Employed in cellular and molecular biology research to elucidate drug resistance mechanisms and synergistic effects.

Basic Information

Product Name	Plevitrexed
CAS No.	153538-08-0
Molecular Formula	C₂₆H₂₉N₇O₆
Molecular Weight	535.56 g/mol
Synonyms	BGC 9331; ZD 9331; (6R)-5,10-Dideazatetrahydrofolic acid; Tomudex analogue; Thymidylate synthase inhibitor ZD9331; Plevitrexed (BGC9331); AG-337 analog; 5,10-Dideaza-5,6,7,8-tetrahydrofolic acid
EINECS	Contact for details

Quality Control

Our Plevitrexed is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) documenting all critical quality attributes is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.