Description

Nolatrexed Dihydrochloride CAS NO 152946-68-4 is a high-purity, small-molecule pharmaceutical compound belonging to the class of thymidylate synthase inhibitors. This compound is of significant interest in oncology research for its potent mechanism of action, which targets DNA synthesis in rapidly dividing cells. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) engaged in the development of novel anticancer therapeutics and biochemical studies.

Application

• Oncology Research & Drug Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel anticancer agents.
• Biochemical Assays: Used as a potent and selective inhibitor of thymidylate synthase in enzymatic studies to understand folate metabolism pathways.
• Pharmacological Studies: Employed in in vitro and in vivo models to investigate efficacy, pharmacokinetics, and mechanism of action.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and chemotherapy resistance research.
• Pharmaceutical Intermediates: Acts as a critical building block or precursor in the synthesis of more complex therapeutic molecules.
• Quality Control & Analytical Testing: Functions as a certified reference material (CRM) for HPLC, LC-MS, and NMR method development and validation in QC laboratories.

Basic Information

Product Name	Nolatrexed Dihydrochloride
CAS No.	152946-68-4
Molecular Formula	C19H19N5O3 • 2HCl
Molecular Weight	454.31 g/mol
Synonyms	AG337 Dihydrochloride; Thymitaq Dihydrochloride; 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid Dihydrochloride; Nolatrexed 2HCl; (S)-2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid Dihydrochloride; 5,8-Dideaza-2-desamino-2-methyl-N10-propargylfolic acid Dihydrochloride; ZD-1694 Dihydrochloride
EINECS	Contact for details

Quality Control

Our Nolatrexed Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.