Description

(+)-Epibatidine CAS NO 152885-09-1 is a potent nicotinic acetylcholine receptor (nAChR) agonist, originally isolated from the skin of an Ecuadorian poison frog. This compound matters as a critical research tool in neuroscience and pharmacology for studying receptor function, pain pathways, and the development of novel analgesics. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and drug discovery.

Application

• Neuroscience Research: As a high-affinity ligand for studying the structure and function of neuronal nicotinic acetylcholine receptors (nAChRs).
• Pharmacological Studies: Used in vitro and in vivo to investigate cholinergic signaling, pain perception, and receptor subtype selectivity.
• Drug Discovery Platform: Serves as a lead compound or reference standard in the development of new non-opioid analgesic agents.
• Biochemical Assays: Employed in competitive binding assays and functional studies to screen and characterize new chemical entities.
• Toxicology Research: Used as a reference toxin in studies of alkaloid effects and natural product pharmacology.

Basic Information

Product Name	(+)-Epibatidine
CAS No.	152885-09-1
Molecular Formula	C11H13ClN2
Molecular Weight	208.69 g/mol
Synonyms	(+)-Epibatidine; (1R,2R,4S)-(+)-2-(6-Chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane; exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane; Epibatidine (natural enantiomer); ABT-418 (related analog); Pyridyl azabicycloheptane
EINECS	Contact for details

Quality Control

Our (+)-Epibatidine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and integrity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be provided to meet the rigorous demands of preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Optical Rotation	Specific range provided on COA
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.