Description

3-Hydroxymethyl Mefenamic Acid Acyl-B-D-Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) mefenamic acid, formed via glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, toxicology studies, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification of mefenamic acid and its metabolites in biological matrices during clinical and pre-clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to investigate the metabolic pathways, clearance mechanisms, and bioavailability of mefenamic acid.
• Bioanalytical Method Development: Essential for developing and validating sensitive and specific HPLC, LC-MS, or LC-MS/MS assays for therapeutic drug monitoring and pharmacokinetic profiling.
• Toxicology and Safety Assessment: Employed in studies to understand the potential toxicity, distribution, and excretion profiles of mefenamic acid metabolites.
• Regulatory Submission Support: Provides essential data for regulatory filings with agencies like the FDA and EMA, supporting the safety and efficacy profile of mefenamic acid.
• Academic Research: Used in university and institutional labs for fundamental research on NSAID metabolism and glucuronidation processes.

Basic Information

Product Name	3-Hydroxymethyl Mefenamic Acid Acyl-B-D-Glucuronide
CAS No.	152832-29-6
Molecular Formula	C23H25NO9
Molecular Weight	459.45 g/mol
Synonyms	Mefenamic Acid 3-Hydroxymethyl Acyl Glucuronide; 3-Hydroxymethyl Mefenamic Acid Glucuronide; 1-O-[2-[(2,3-Dimethylphenyl)amino]-3-(hydroxymethyl)benzoyl]-β-D-glucopyranuronic Acid; Mefenamic Acid Metabolite Glucuronide; N-(2,3-Dimethylphenyl)anthranilic Acid 3-Hydroxymethyl Glucuronide; 3-Carboxy-2',3'-dimethylbenzoyl glucuronide (related); Mefenamic Acid Acyl Glucuronide Derivative
EINECS	Contact for details

Quality Control

Our high-purity reference standards are produced under strict quality control protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to ensure identity, purity, and stability. Certificates of Analysis (COA) are provided, detailing batch-specific results for assay, impurities, and chromatographic profile. We support compliance with ICH guidelines for analytical validation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to prevent degradation. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.